Electrical induction of coronary artery thrombosis in the ambulatory canine: a model for in vivo evaluation of anti-thrombotic agents.
نویسندگان
چکیده
A simple technique for the reliable induction of coronary artery thrombosis in a conscious dog by delivery of low amperage electric current to the intimal surface of the artery io described. Ibuprofen, an agent known to inhibit platelet function and ptostaglandin synthesis is evaluated in this model. Comparison of myocardial infarct site, throabur weight, arrhythmia development and scanning electron nicrographs of drug treated and control animals indicate that Ibuprofen is capable of protecting against the deleterious effects of coronary artery thrombosis produced by this technique. This method holds considerable potential as an ;iD. vivq model of coronary artery thrombosis and one in which evaluation of anti-thrw botic agents is possible.
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ورودعنوان ژورنال:
- Thrombosis research
دوره 17 6 شماره
صفحات -
تاریخ انتشار 1980